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Complication
/ˌkɒmpləˈkeɪʃən/
An obstacle or issue that makes a situation more difficult or complex.
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Examples:
Fear of complications?
But he was soon back again, perturbed by a new complication.
That was a complication which was to dawn later.
Etymology:
Originated in the mid-14th century from the Old French term complication or directly from Latin complicationem, meaning a combination, intricacy, or obstruction.